Locked away by her own choice in the perceived safety of a psychiatric hospital, the lone survivor from Final Destination lives in constant terror that Death is coming to claim her. She may be considered crazy, but she's not wrong. Death is moving toward suburban Route 23, heading south in Final Destination 2. Meanwhile, en route to a weekend getaway with her friends, Kimberly Corman (A.J. COOK) has a terrible premonition ... Shocked into action, Kimberly blocks traffic on a highway onramp. Drivers honk and complain--until Death tears up the highway in a massive pile-up, with those left on the onramp narrowly escaping with their lives. But Kimberly knows it's not over: Death won't be cheated so easily. Now this random group of strangers, who were all meant to die in the freeway disaster, must join Kimberly in a desperate attempt to stay alive.
